PREPARATION OF SUBSTITUTED QUINOXALINES FROM THE DIANLINE WITH 2,3-DIHYDROXY-1,4-DIOXANE

The present invention relates to a new process for the preparation of substituted quinoxalines (I) by cyclization of the corresponding dianiline with 2,3 dihydroxy-1,4-dioxane. In a preferred embodiment, the invention provides a process for the preparation of compounds having the formula III wherein...

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Bibliographic Details
Main Author RAINVILLE, JOSEPH PHILIP
Format Patent
LanguageEnglish
Spanish
Published 02.03.2006
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to a new process for the preparation of substituted quinoxalines (I) by cyclization of the corresponding dianiline with 2,3 dihydroxy-1,4-dioxane. In a preferred embodiment, the invention provides a process for the preparation of compounds having the formula III wherein Q is a nitrogen protecting group. Compounds of formula III and their derivatives are precursors to certain aryl fused azapolycyclic compounds which exhibit activity as agents for the treatment of neurological and psychological disorders. La presente invencion se refiere a un nuevo procedimiento para preparar quinoxalinas sustituidas (I) por ciclacion de la dianilina correspondiente con 2,3-dihidroxi-1,4-dioxano; en una modalidad preferida, la invencion proporciona un procedimiento para preparar compuestos que tienen la formula (ver formula III): en la que Q es un grupo protector de nitrogeno; los compuestos de formula III y sus derivados son precursores de ciertos compuestos azapoliciclicos condensados con arilo que presentan actividad como agentes para le tratamiento de trastornos neurologicos y psicologicos.
Bibliography:Application Number: MX2005PA13084