NOVEL CRYSTAL FORMS OF ONDANSETRON, PROCESSES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THE NOVEL FORMS AND METHODS FOR TREATING NAUSEA USING THEM

• Main Author: TIVADAR TAMAS
• Format: Patent
• Language: English; Spanish
• Published: 25.01.2005
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SEPARATION; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRANSPORTING

Ondansetron crystalline Forms A and B are useful in the treatment of nausea and vomiting. Form B has uniquely high melting point of about 244 degree C and both forms are stable against thermally induced polymorphic transition from 30 degree C up to their melting points. Las Formas A y B cristalinas de ondansetron son utiles en el tratamiento de nauseas y vomitos. La Forma B tiene un punto de fusion alto unico de 244 degree C y ambas formas son estables contra la transicion polimorfica inducida termicamente desde 30 degree C hasta su punto de fusion.