PIPERIDINE DERIVATIVE COMPOUNDS AND DRUGS CONTAINING THE COMPOUNDS AS THE ACTIVE INGREDIENT

• Main Author: TAZUMI OHTANI
• Format: Patent
• Language: English; Spanish
• Published: 10.11.2004
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Piperidine derivatives represented by the following general formula (I) (wherein each symbol is as defined in the description) and production intermediates thereof: (I) Because of having a phosphodiesterase 4 inhibitory activity, the compounds represented by the general formula (I) are useful in preventing and/or treating inflammatory diseases, diabetic diseases, allergic diseases, autoimmune diseases, eye diseases, osteoporosis, bone fracture, arthritis deformans, obesity, overeating, depression, ParkinsonaC¦s disease, dementia, ischemic reperfusion injury, leukemia, acquired immunodeficiency syndrome (AIDS), shock, systemic inflammatory response syndrome (SIRS), etc. La presente invencion se refiere a un derivado de piperidina de la Formula (I)(ver formula I)(en donde todos los simbolos son como los descritos en la descripcion) y un intermediario para la preparacion del mismo. El compuesto de la Formula (I) tiene actividad inhibitoria de la fosfodiesterasa 4 y es util para la prevencion y/o el tratamiento de enfermedades inflamatorias, enfermedades diabeticas, enfermedades alergicas, enfermedades autoinmunitarias, enfermedades oculares, osteoporosis, fractura de huesos, osteoartritis, obesidad, bulimia, depresion, enfermedad de Parkinson, demencia, lesiones por reperfusion isquemica, leucemia, sindrome de inmunodeficiencia adquirida (SIDA), estado de choque, enfermedades inflamatorias sistemicas (EIS), etc.