PREPARATION OF PHARMACEUTICAL SALTS OF 4 ( (Z) - (4-BROMOPHENYL) (ETHOXYIMINO) METHYL )-1'-( (2,4-DIMETHYL-1-OXIDO-3-PYRIDINYL) CARBONYL) -4'-METHYL-1,4' BIPIPERIDINE AS CCR5-ANTAGONISTS FOR THE TREATMENT OF AIDS AND RELATED HIV INFECTIONS

A process for preparing a mixture of rotamers or rotamer pairs of a salt of a basic compound of formula (I) wherein said mixture comprises one or more rotamers or rotamer pairs of the salt in a higher molar percent than other corresponding rotamers or rotamer pairs of the salt, said process comprisi...

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Bibliographic Details
Main Author TANG, SUHAN
Format Patent
LanguageEnglish
Spanish
Published 11.08.2004
Edition7
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:A process for preparing a mixture of rotamers or rotamer pairs of a salt of a basic compound of formula (I) wherein said mixture comprises one or more rotamers or rotamer pairs of the salt in a higher molar percent than other corresponding rotamers or rotamer pairs of the salt, said process comprising reacting said basic compound with an acid in admixture with a solvent. Un procedimiento para preparar una mezcla de rotameros o pares rotamericos de una sal de un compuesto basico de formula (1), donde dicha mezcla comprende uno o mas rotameros o pares de rotameros de la sal en un porcentaje molar superior al de sus otros correspondientes rotameros o pares de rotameros de dicha sal, dicho procedimiento comprende 15 hacer reaccionar dicho compuesto basico con un acido en mezcla solvente.
Bibliography:Application Number: MX2004PA05155