NOVEL HYDROXY CYCLOHEXENYL PHENYL CARBOXAMIDES TOCOLYTIC OXYTOCIN RECEPTOR ANTAGONISTS

• Main Author: WILLIAM JENNINGS SANDERS
• Format: Patent
• Language: English; Spanish
• Published: 12.11.2004
• Edition: 7
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention provides substituted 10, 11-Dihydro-5H-benzo[e]-pyrrolo-[1,2-a][1,4]diazepine and 9,10-Dihydro-4H-3a,5,9-triaza-benzo[f]azulene compounds as well as methods and pharmaceutical compositions utilizing these compounds for the treatment and/or prevention and/or supression of disorders which may be remedied or alleviated by oxytocin antagonist activity, including prevention and/or suppression of preterm labor, suppression labor at term prior to caesarean deliver, and for the treatmet of dysmenorrhea. These compounds are also useful in enhancing fertility rates, enhancing survival rates and synchronizing estrus in farm animals. La presente invencion proporciona compuestos de 10,11-dihidro-5H-benzo [c] -pirrolo[1,2-a]diazepina y 9,10-dihidro-4H-3a,5,9-triaza-benzo [f]azuleno, asi como metodos y composiciones farmaceuticas que utilizan estos compuestos para el tratamiento y/o prevencion y/o supresion de trastornos que pueden remediarse o aliviarse por la actividad antagonista de la oxitocina, incluyendo la prevencion y/o supresion del parto prematuro, la represion del parto a termino antes de practicar una cesarea, y para el tratamiento de la dismenorrea. Estos compuestos tambien son utiles para mejorar las tasas de fertilidad, para mejorar las tasas de supervivencia, asi como para sincronizar el estro en animales de granja.