PROCESS FOR PREPARING FINE PARTICLE PHARMACEUTICAL FORMULATIONS

A process for preparing fine particle pharmaceutical formulations having improved throughput and producing greater uniformity of particle size comprises adding to the dry components of the formulation prior to the steps of wetting, extrusion and spheronization, an extrusion aid material selected fro...

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Bibliographic Details
Main Authors ROBERT W. KOHLER, CLAUD LOYD, SUSAN J. SEMLA, PRAMOD K. GUPTA, JACQUELINE E. BRISKIN
Format Patent
LanguageEnglish
Spanish
Published 31.12.1997
Edition6
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A process for preparing fine particle pharmaceutical formulations having improved throughput and producing greater uniformity of particle size comprises adding to the dry components of the formulation prior to the steps of wetting, extrusion and spheronization, an extrusion aid material selected from pharmaceutically acceptable oils and waxes having a drop point between about 15 degree C and 115 degree C. Un procedimiento para preparar formulaciones farmacéuticas en partículas finas que tiene una produccion mejorada y que produce una uniformidad mayor de tamaño de partícula, comprende añadir a los componentes en seco de la formulacion, antes de los pasos de humedecimiento, extrusion, y esferonizacion, un material auxiliar de extrusion seleccionado de aceites y ceras farmacéuticamente aceptables que tienen un punto de caída de entre aproximadamente 15 degree C y 115 degree C.
Bibliography:Application Number: MX19960003480