METODO PARA PRODUCIR DISPOSITIVOS DE SUMINISTRO POROSO

• Main Author: JULIAN B. LO
• Format: Patent
• Language: Spanish
• Published: 01.10.1993
• Edition: 5
• Subjects: BABY COMFORTERS; CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICALPURPOSES; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; DEVICES FOR RECEIVING SPITTLE; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGINGPHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL ORADMINISTERING FORMS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Un método eficaz de fabricación de dispositivos de descarga de gran resistencia, muy porosos y de rápida disolución. El método consiste en mezclar un formulado que comprende mentol, un polímero soluble en agua y soluble en mentol y un agente activo, a una temperatura tal que el mentol está sustancialmente fundido. PCT No. PCT/US92/09321 Sec. 371 Date Sep. 15, 1994 Sec. 102(e) Date Sep. 15, 1994 PCT Filed Nov. 6, 1992 PCT Pub. No. WO93/18757 PCT Pub. Date Sep. 30, 1993.An efficient method for making high strength, highly porous, fast dissolving delivery devices. The method comprises mixing a formulation comprising menthol, a water-soluble, menthol-soluble polymer, and an active agent at a temperature such that the menthol is substantially molten. The formulation is disposed in a mold, solidified and the menthol is sublimed from the solidified molded formulation. Preferably, the solidification occurs at a temperature sufficient to provide a substantially amorphous menthol structure.