PROCEDIMIENTO PARA PREPARAR PEPTIDOS

Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure: X-β-D-2NAL-...

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Bibliographic Details
Main Authors WYLIE WALKER VALE, JR, JEAN EDOUARD FREDERIO RIVIER
Format Patent
LanguageSpanish
Published 11.05.1988
Edition4
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Peptides which inhibit the secretion of gonadotropins by the pituitary gland and inhibit the release of steroids by the gonads. Administration of an effective amount prevents ovulation of female mammalian eggs and/or the release of steroids by the gonads. The peptides have the structure: X-β-D-2NAL-R2-D-Trp-Ser-R5-R6-R7-Arg-Pro-R wherein X is hydrogen or an acyl group having 7 or less carbon atoms; R2 is Cl-D-Phe, F-D-Phe, N02-D-Phe, Cl2-D-Phe or Br-D-Phe; R5 is Tyr or Cl-Phe; R6 is 4-NH2-D-Phe or D-Arg; R7 is Leu or NαMe-Leu; and R10 is Gly-NH2, NHCH2CH3 or D-Ala-NH2.
Bibliography:Application Number: MX19830010714U