CAROTENOID DERIVATIVE, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND PHARMACEUTICALLY ACCEPTABLE ESTER OR AMIDE THEREOF

• Main Authors: FUJITA, Takashi, Satoshi KOBAYASHI, Ryoma SHINOHARA, Jiro TAKAHASHI, Yasuhiro NISHIDA
• Format: Patent
• Language: English; Spanish
• Published: 05.04.2019
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention addresses the problem of discovering a carotenoid compound exhibiting excellent water solubility. Provided is a carotenoid derivative represented by general formula (I) [in general formula (I): X represents a carbonyl group or a methylene group; R1 and R2 represent (a), namely -CO-A-B-D (in (a), A represents an alkylene group, an alkenylene group, or the like, B represents the formula -S(O)n-, or the formula -NR4CONR5-, and D represents hydrogen, a carboxyl group, or the like), or (b), namely -CO-E-F (in (b), E represents an alkylene group, or the formula -NR3- {wherein R3 represents (a1) hydrogen, (b1) an alkyl group, or the like}, and F represents a sulfo group); and the remainder comprises hydrogen, (a), (b), or (c), namely -CO-G (in (c), G represents hydrogen, an alkyl group, or the like)]. Also provided are: a pharmaceutically acceptable salt of the carotenoid derivative; and a pharmaceutically acceptable ester or amide of the carotenoid derivative. El objetivo de la presente invención es encontrar un compuesto carotenoide que es excelente en solubilidad en agua; un derivado de carotenoides que tiene una fórmula (I): (ver Fórmual) en donde X representa un grupo carbonilo o un grupo metileno, uno de R1 y R2 representa (a) o (b) y el otro representa (a), (b), (c) o un átomo de hidrógeno: (a): -CO-A-B-D en donde A representa un grupo alquileno, un grupo alquenileno, etc., B representa una fórmula de -S(O)n- o una fórmula de -NR4CONR5- y D representa un átomo de hidróegeno, un grupo carboxilo, etc., (b): -CO-E-F en donde E representa un grupo alquíleno o una fórmula de -NR3- en donde R3 representa (a1) un átomo de hidrógeno, (b1) un grupo alquilo, etc., y F representa un grupo sulfo y (c): -CO-G en donde G representa un átomo de hidrógeno, un grupo alquilo, etc., una sal farmacéuticamente aceptable del mismo, o un éster o una amida farmacéuticamente aceptables del mismo.