SLOW INTRAVENTRICULAR DELIVERY

Neurological diseases, including lysosomal storage diseases, can be successfully treated using intraventricular delivery of the therapeutic agents to bypass the blood-brain barrier. Similarly, diagnostic agents and anesthetic agents can be delivered to the brain in this manner. The administration ca...

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Bibliographic Details
Main Authors PASSINI, Marco, DODGE James, Lamya SHIHABUDDIN, CHENG, Seng
Format Patent
LanguageEnglish
Spanish
Published 17.12.2018
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Neurological diseases, including lysosomal storage diseases, can be successfully treated using intraventricular delivery of the therapeutic agents to bypass the blood-brain barrier. Similarly, diagnostic agents and anesthetic agents can be delivered to the brain in this manner. The administration can be performed slowly to achieve maximum effect. Such administration permits greater penetration of distal portions of the brain. Las enfermedades neurológicas, que incluyen enfermedades de almacenamiento lisosomal, pueden ser tratadas exitosamente utilizando la administración intraventricular de agentes terapéuticos para pasar la barrera sanguíneo-cerebral. De manera similar, los agentes de diagnóstico y agentes anestésicos pueden ser administrados al cerebro de esa forma. La administración puede llevarse a cabo lentamente para lograr el máximo efecto. Dicha administración permite mayor penetración de porciones distales del cerebro.
Bibliography:Application Number: MX20130013333