METHOD FOR AVOIDING OR DELAYING THE ALLODYNIA APPARITION BY MEANS OF A TREATMENT OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS

The present invention describes the use of angiotensin-converting enzyme inhibitors (ACEI) for avoiding or delaying the appearance of allodyne, especially in diabetic patients. According to the invention, diabetes and allodyne were previously induced in rats by means of streptozotocin, some rats sub...

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Bibliographic Details
Main Authors CLAUDIA IVONNE ARAIZA SALDAÑA, ENRIQUE HONG CHONG, VINICIO GRANADOS SOTO
Format Patent
LanguageEnglish
Spanish
Published 16.10.2018
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:The present invention describes the use of angiotensin-converting enzyme inhibitors (ACEI) for avoiding or delaying the appearance of allodyne, especially in diabetic patients. According to the invention, diabetes and allodyne were previously induced in rats by means of streptozotocin, some rats subsequently treated with fosinopril shown no allodyne at any time during the experiment, so that the invention being the first report showing the anti-allodyne effect of fosinopril. La presente invención se refiere a el uso de inhibidores de la enzima convertidora de angiotensina (inhibidor de la ECA), para evitar o retrasar la aparición de alodinia, especialmente en el paciente diabético. Conforme a la invención por ejemplo, ratas donde se indujo previamente diabetes y alodinia mediante estreptozotocina y a las que se les administró posteriormente fosinopril, no mostraron alodinia a ningún tiempo durante la duración del experimento, por lo que la invención es el primer reporte en donde se demuestra el efecto antialodínico del fosinopril.
Bibliography:Application Number: MX20120006195