NOVEL CEPHALOSPORIN DERIVATIVE AND MEDICAL COMPOSITION CONTAINING SAME

• Main Authors: Young Jae YANG, Yong Zu KIM, Chul Soon PARK, Hyun Jin KWON, Joung Yul YUN, Hye Jin HEO, Kyuman OH, Dae Hyuck KANG, Tae Kyo PARK, Sung Ho WOO, Young Lag CHO, San Eun CHAE, Hyang Sook LEE
• Format: Patent
• Language: English; Spanish
• Published: 28.09.2018
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to a novel cephalosporin derivative indicated in chemical formula 1 of the description. In the chemical formula 1, X, Y, L, R1, R2 are identical as defined in the detailed explanation. In addition, the present invention relates an antibiotic medical composition containing the novel cephalosporin derivative of the chemical formula 1, a prodrug thereof, a hydrate thereof, a solvate thereof, an isomer thereof, and a pharmaceutically permitted salt thereof, as active ingredients. The novel cephalosporin derivative of the chemical formula 1, the prodrug thereof, the hydrate thereof, the solvate thereof, the isomer thereof, and the pharmaceutically permitted salt thereof have a wide antibacterial spectrum for resistant bacteria, have low toxicity, and in particular, show strong antibacterial effect on gram negative bacteria, and is thus useful as an antibiotic. La presente invención se refiere a derivados novedosos de cefalosporinas representados por la fórmula química 1. (Ver Formula) Donde X, Y, L, R1 y R2 son los mismos que se han definido en la descripción de la invención. La presente invención también se refiere a composiciones antibióticas farmacéuticas que comprenden un derivado novedoso de cefalosporinas representado por la fórmula química 1, un profármaco de este, un hidrato de este, un solvato de este, un isómero de este o una sal farmaceúticamente aceptable de este como principio eficaz. De acuerdo con la presente invención, los derivados novedosos de cefalosporinas, un profármaco de estos, un hidrato de estos, un solvato de estos, un isómero de estos o una sal farmacéuticamente aceptable de estos pueden ser útiles como antibióticos debido a su amplio espectro contra bacterias resistentes a antibióticos, su baja toxicidad y especialmente su potente efecto antibacteriano en bacterias gramnegativas.