DNA-PK INHIBITORS

The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such...

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Main Authors Huai GAO, John P. DUFFY, Joseph M. KENNEDY, Katrina Lee JACKSON, Simon GIROUX, Jeremy GREEN, Pan LI, Nathan D. WAAL, Hongbo DENG, John Patick MAXWELL, Jinwang XU, David J. LAUFFER, Albert Charles PIERCE, Paul S. CHARIFSON, Kevin Michael COTTRELL, Mark Willem LEDEBOER, Mark A. MORRIS
Format Patent
LanguageEnglish
Spanish
Published 03.07.2018
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The present invention relates to compounds of following formula (I) useful as inhibitors of DNA-PK. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders, such as cancer. La presente invención se refiere a compuestos de la fórmula siguiente: (ver Fórmula) que son útiles como inhibidores de la ADN-PK. La invención proporciona, además, composiciones farmacéuticamente aceptables que comprenden esos compuestos, y métodos para usar las composiciones en el tratamiento de diversas enfermedades, afecciones o trastornos, tales como el cáncer.
Bibliography:Application Number: MX20140012960