NON-LEACHING SURFACE-ACTIVE FILM COMPOSITIONS FOR MICROBIAL ADHESION PREVENTION

• Main Authors: KAREN MERRITT, XIN QU, VITALY FALEVICH, RAINER GRUENING, PAUL N. CHEN
• Format: Patent
• Language: English; Spanish
• Published: 26.04.2018
• Subjects: AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G; APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TO SURFACES, IN GENERAL; BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMISTRY; COMPOSITIONS BASED THEREON; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; GENERAL PROCESSES OF COMPOUNDING; HUMAN NECESSITIES; HYGIENE; MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONSONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PERFORMING OPERATIONS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES FOR APPLYING LIQUIDS OR OTHER FLUENT MATERIALS TOSURFACES, IN GENERAL; PROSTHESES; SPRAYING OR ATOMISING IN GENERAL; THEIR PREPARATION OR CHEMICAL WORKING-UP; TRANSPORTING; TREATMENT OR PROTECTION OF EYES OR EARS; WORKING-UP

Surface-active, non-leaching antimicrobial film forming compositions and methods for their application to preferably medical device surfaces are provided. The compositions form durable coatings with long-lasting antimicrobial efficacy without formation of a zone of inhibition. Optionally the films can be hydrophilic. Specific long-chain molecules of certain chemical reactivity are covalently bonded into a polymeric matrix. They maintain a long-term anti-microbial efficacy without being leached out into the aqueous environment. The polymeric matrix of the compositions contain functional groups, which covalently bond to an amine, thiol, carboxyl, aldehyde or hydroxyl active group of selected long chain quaternary ammonium compounds. Upon formation of a covalent bonding with the polymeric matrix the long chain compounds become immobilized but still maintain antimicrobial efficacy. They do not leach out over extended period of time into the aqueous environment and maintain an anti-microbial efficacy against microorganisms. The coating is useful to prevent bacterial colonization on a variety of surface including surfaces of medical devices. Composiciones que forman película antimicrobiana que no se lixivia, activas en superficie y métodos para su aplicación a preferentemente superficies de dispositivos médicos se proporcionan. Las composiciones forman recubrimientos durables con eficacia antimicrobiana de larga duración sin formación de una zona de inhibición. Opcionalmente las películas pueden ser hidrófilas. Moléculas de cadena larga específicas de cierta reactividad química se enlazan de manera covalente en una matriz polimérica. Mantienen una eficacia antimicrobiana de largo plazo sin lixiviarse hacia el ambiente acuoso. La matriz polimérica de las composiciones contiene grupos funcionales, los cuales se enlazan de manera covalente a un grupo activo de amina, tiol, carboxilo, aldehído o hidroxilo de compuestos de amonio cuaternario de cadena larga seleccionados. Ante la formación de un enlace covalente con la matriz covalente los compuestos de cadena larga se vuelven inmovilizados pero aun mantienen eficacia antimicrobiana. No se lixivian sobre periodos de tiempo extendidos hacia el ambiente acuoso y mantienen una eficacia antimicrobiana contra microorganismos. El recubrimiento es útil para prevenir colonización bacteriana en una variedad de superficies incluyendo superficies de dispositivos médicos.