COMPOUNDS AND THEIR USE

• Main Authors: Hariharan Periasamy, Senthilkumar Udayampalayam Palanisamy, Shridhar Narayanan, Aravind Appu, Senthilnathan Manickam, Gopalan Balasubramanian, Maneesh Paul-Satyaseela
• Format: Patent
• Language: English; Spanish
• Published: 11.01.2018
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS OR TEST PAPERS THEREFOR; COMPOSITIONS THEREOF; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES; CULTURE MEDIA; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROCESSES OF PREPARING SUCH COMPOSITIONS; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Described herein are compounds and their use in the treatment of infections. The compound of formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, solvates, pharmaceutically acceptable salts and pharmaceutical compositions described herein are also useful as ß -lactamase inhibitors, which restore or enhance the antibiotic spectrum of a suitable antibiotic agent. The compounds of formula (I) act as inhibitors of ß-lactamases. These compounds restore/potentiate the activities of ß-lactam antibiotics against carbapenemases. These compounds find use in diagnostic method for detecting ß-lactamases. Formula (I). En la presente invención se describen compuestos y su uso en el tratamiento de infecciones. El compuesto de la fórmula (I), sus derivados, análogos, formas tautoméricas, estereoisómeros, polimorfos, solvatos, sales farmacéuticamente aceptables y composiciones farmacéuticas aquí descritas, también son útiles como inhibidores de ß-lactamasa, que restauran o incrementan el espectro antibiótico de un agente antibiótico adecuado. Los compuestos de la fórmula (I) actúan como inhibidores de ß-lactamasas. Estos compuestos restauran/potencían las actividades de los antibióticos de ß-lactam contra carbapenemasas. Estos compuestos encuentran uso en el método de diagnóstico para detectar ß-lactamasas. Fórmula (I).