MORPHOLINE-SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS

The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders....

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Main Authors Pramod JOSHI, Michael Paul DENINNO, Edward Adam KALLEL, Joseph PONTILLO, Lev Tyler Dewey FANNING, Nicole HILGRAF, Urvi Jagdishbhai SHETH, Hayley Marie BINCH, Peter Diederik Jan GROOTENHUIS, Alina SILINA, Vijayalaksmi ARUMUGAM, Mark Thomas MILLER, Sara Sabina HADIDA-RUAH, Bryan A. FRIEMAN, Dennis James HURLEY
Format Patent
LanguageEnglish
Spanish
Published 22.05.2017
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention relates to morpholine spirocyclic piperidine amide compounds useful as inhibitors of ion channels. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. La invención se refiere a compuestos de morfolina-piperidina espirocíclica-amida útiles como inhibidores de canales iónicos. La invención también proporciona composiciones farmacéuticamente aceptables que comprenden los compuestos de la invención y métodos para usar las composiciones en el tratamiento de varios trastornos.
Bibliography:Application Number: MX20130010476