TRANSDERMAL ADHESIVE COMPOSITIONS, DEVICES, AND METHODS

• Main Authors: ELIZABETH E. JOHNSON, AMY PRESZLER PRINCE, ZHENG ZHI WU, JAMES P. DIZIO
• Format: Patent
• Language: English; Spanish
• Published: 03.03.2017
• Subjects: ADHESIVE PROCESSES NOT PROVIDED FOR ELSEWHERE; ADHESIVES; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; CHEMISTRY; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; DYES; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METALLURGY; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; MISCELLANEOUS APPLICATIONS OF MATERIALS; MISCELLANEOUS COMPOSITIONS; NATURAL RESINS; NON-MECHANICAL ASPECTS OF ADHESIVE PROCESSES IN GENERAL; PAINTS; POLISHES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; USE OF MATERIALS AS ADHESIVES

A stable transdermal adhesive composition comprising: an adhesive comprising a washed polymerization reaction product of at least two ethylenically unsaturated monomers; and at least one pharmaceutically active compound which is susceptible to oxidative degradation; wherein the at least two ethylenically unsaturated monomers, if present in the adhesive as unreacted monomers, are present at a level of less than 200 ppm of total unreacted monomer, based upon the total weight of the adhesive, methods of making the composition, a transdermal drug delivery device using the composition, methods of making the device, and methods of delivery the pharmaceutically active compound are provided. Se describe una composición adhesiva transdérmica, estable, que comprende: un adhesivo que comprende un producto lavado de reacción de polimerización de al menos dos monómeros etilénicamente insaturados; y al menos un compuesto farmacéuticamente activo que es susceptible a la degradación oxidativa; en donde al menos dos monómeros etilénicamente insaturados, si están presentes en el adhesivo como los monómeros sin reaccionar, están presentes a un nivel de menos de 200 ppm del monómero sin reaccionar total, con base en el peso total del adhesivo, los métodos de elaboración de la composición, un dispositivo de administración transdérmica de fármaco que utiliza la composición, los métodos de elaboración el dispositivo, y los métodos de distribución del compuesto farmacéuticamente activo.