ANTIBODIES WITH ENHANCED OR SUPPRESSED EFFECTOR FUNCTION

• Main Authors: ERIC ESCOBAR-CABRERA, DUSTIN BLEILE, DAVID K. Y. POON, IGOR D'ANGELO, STACEY A.L. TOM-YEW, SURJIT B. DIXIT, ANDERS OHRN, PAULA I LARIO
• Format: Patent
• Language: English; Spanish
• Published: 07.09.2016
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

Rationally designed antibodies and polypeptides that comprise multiple Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides are mutated at multiple positions to make them more effective when incorporated in antibody therapeutics than those having wild-type Fc components. La presente invención se refiere a un polipéptido que comprende una región Fc variante, en donde dicha región Fc variante comprende modificaciones de aminoácidos con relación a una región Fc tipo natural, dichas modificaciones de aminoácidos comprende una mutación en la posición 239 y además comprenden la mutación D265S, en donde la numeración de residuos de aminoácidos es de acuerdo al índice EU como se establece en Kabat, y en donde la mutación en la posición 239 es S239D o S239E.