BISPECIFIC ANTIBODIES

• Main Authors: CHRISTIAN KLEIN, ULRICH BRINKMANN, JUERGEN MICHAEL SCHANZER, KATHARINA WARTHA, JOERG THOMAS REGULA, REBECCA CROASDALE, ERHARD KOPETZKI, WILMA LAU, PABLO UMANA, HARALD DUERR
• Format: Patent
• Language: English; Spanish
• Published: 28.06.2016
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present invention relates to bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. The present invention relates to bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. Substituted pyridazines of the formula (I) in which the variables are defined according to the description, processes and intermediates for preparing the compounds of the formula (I) and their N-oxides, their agriculturally suitable salts, compositions comprising them and their use as herbicides, and also methods for controlling unwanted vegetation. La presente invención se refiere a un anticuerpo biespecífico, caracterizado porque comprende: a) la cadena pesada y la cadena ligera de un primer anticuerpo de longitud completa que se une específicamente aun primer antígeno; b) la cadena pesada y la cadena ligera de un segundo anticuerpo de longitud completa que se une específicamente a un segundo antígeno, en donde la parte N-terminal de la cadena pesada se conecta a la parte C-terminal de la cadena ligera por medio de un enlazante peptídico.