CRYSTALLINE FORMS OF AN MCL-1 INHIBITOR

• Main Authors: PARENT Stephan, XIAO Lingyun, ACHMATOWICZ Michal, KELLY Ron C, REID Darren L, TENG Jing, LUU Van, CHAVES Mary, FARRELL Robert P, STEC Markian, HUCKLE James E, WU Tian
• Format: Patent
• Language: English; Spanish
• Published: 15.08.2024
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Disclosed herein are crystalline forms of (4S,7aR,9aR, 10R, 11E, 14S, 15R)-6'-chloro-10-methoxy-14, 15- dimethyl-10-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]meth yl}-3',4',7a,8,9,9a,10, 13, 14, 15-decahydro- 2'H, 3H, 5H-spiro[1,19-etheno-1616-cyclobuta[i] [1,4] oxazepino[3, 4-f] [1,2,7]thiadiazacyclohexadecine-4,1'- naphthalene]-16, 16, 18(7H, 17H)-trione (AMG 397): (AMG 397), hydrates, and solvates thereof. Also disclosed are methods of making the crystalline forms, and methods of treating diseases and disorders with the crystalline forms. Se divulgan en el presente documento formas cristalinas de (4S,7aR,9aR,10R,11E,14S,15R)-6'-cloro-10-metoxi-14,15-dimetil-10- {[(9aR)-octahidro-2H-pirido[1,2-a]pirazin-2-il]metil}-3',4',7a,8, 9,9a,10,13,14,15-decahidro-2'H,3H,5H-spiro[1,19-eteno-16l6-ciclob uta[i][1,4]oxazepino[3,4-f][1,2,7]tiadiazaciclohexadecina-4,1'-na ftaleno]-16,16,18(7H,17H)-triona (AMG 397): (AMG 397), sus hidratos y solvatos. También se divulgan métodos para fabricar las formas cristalinas y métodos para tratar enfermedades y trastornos con las formas cristalinas.