ANTIBODIES SPECIFIC FOR FLT3 AND THEIR USES

The present invention provides antibodies that specifically bind to FLT3 (Fms- Like Tyrosine Kinase 3). The invention further provides bispecific antibodies that bind to FLT3 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining s...

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Bibliographic Details
Main Authors POULSEN Kristian Todd, YEUNG Yik Andy, SOMMER Cesar Adolfo, DETTLING Danielle Elizabeth, KRISHNAMOORTHY Veena
Format Patent
LanguageEnglish
Spanish
Published 21.06.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present invention provides antibodies that specifically bind to FLT3 (Fms- Like Tyrosine Kinase 3). The invention further provides bispecific antibodies that bind to FLT3 and another antigen (e.g., CD3). The invention further relates to antibody encoding nucleic acids, and methods of obtaining such antibodies (monospecific and bispecific). The invention further relates to therapeutic methods for use of these antibodies for the treatment of FLT3-mediated pathologies, including cancer such as Acute Myeloid Leukemia (AML). La presente invención proporciona anticuerpos que se unen específicamente a FLT3 (Tirosina quinasa tipo Fms 3). La invención proporciona además anticuerpos biespecíficos que se unen a FLT3 y a otro antígeno (por ejemplo, CD3). La invención se refiere además a ácidos nucleicos que codifican anticuerpos, y a métodos para obtener tales anticuerpos (monoespecíficos y biespecíficos). La invención se refiere además a métodos terapéuticos para el uso de estos anticuerpos para el tratamiento de patologías mediadas por FLT3, que incluyen cáncer tal como leucemia mieloide aguda (AML).
Bibliography:Application Number: MX20240007079