APTAMERS FOR PERSONAL HEALTH CARE APPLICATIONS

• Main Authors: PITZ Adam Michael, TREJO Amy Violet, WAGNER Matthew Scott, SCHMEICHEL Kelly Lee, RUPARD Spencer Christopher, VELASQUEZ Juan Esteban, SWIGART Erin Nicole, NAMANJA-MAGLIANO Hilda Andamiche, PENNER Gregory Allen
• Format: Patent
• Language: English; Spanish
• Published: 28.05.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

An aptamer composition is disclosed which has one or more oligonucleotides that include at least one of deoxyribonucleotides, ribonucleotides, derivatives of deoxyribonucleotides, derivatives of ribonucleotides, or mixtures thereof. The aptamer composition has a binding affinity for one or more cellular membrane glycoproteins selected from the group consisting of: intercellular adhesion molecule 1 (ICAM-1), low-density lipoprotein receptor (LDLR) family members, and cadherin-related family member 3 (CDHR3), preferably intercellular adhesion molecule 1 (ICAM-1), and is configured to reduce the binding of one or more human rhinoviruses to the intercellular adhesion molecule 1 (ICAM-1). Se describe una composición de aptámeros que tiene uno o más oligonucleótidos que incluyen al menos uno de desoxirribonucleótidos, ribonucleótidos, derivados de desoxirribonucleótidos, derivados de ribonucleótidos, o mezclas de estos. La composición de aptámeros tiene una afinidad de unión por una o más glicoproteínas de membrana celular seleccionadas del grupo que consiste en: molécula de adhesión intercelular 1 (ICAM-1), miembros de la familia del receptor de lipoproteínas de baja densidad (LDLR), y miembro de la familia relacionada a cadherina 3 (CDHR3), preferentemente molécula de adhesión intercelular 1 (ICAM-1), y se configura para reducir la unión de uno o más rinovirus humanos a la molécula de adhesión intercelular 1 (ICAM-1).