SPIROTRICYCLE RIPK1 INHIBITORS AND METHODS OF USES THEREOF

Described herein are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein A, R1, R2, R3, W, X, Y, Z, m, n and p are as defined herein. The compounds of Formula I act as RIPK1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for RIPK1-relate...

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Main Authors BRILL Zachary, G, METHOT Joey, L, FRADERA Xavier, RICO DUQUE Jenny Lorena, SU Jing, VARA Brandon, A, SILIPHAIVANH Phieng, ACHAB Abdelghani Abe, DIMAURO Erin, F
Format Patent
LanguageEnglish
Spanish
Published 13.05.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Described herein are compounds of Formula I: or a pharmaceutically acceptable salt thereof, wherein A, R1, R2, R3, W, X, Y, Z, m, n and p are as defined herein. The compounds of Formula I act as RIPK1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for RIPK1-related diseases. En el presente documento se describen compuestos de Fórmula I: (ver Fórmula) I o una sal farmacéuticamente aceptable del mismo, en donde A, R1, R2, R3, W, X, Y, Z, m, n y p son como se definen en el presente documento. Los compuestos de Fórmula I actúan como inhibidores de RIPK1 y pueden ser útiles en la prevención, el tratamiento o la actuación como agente curativo para enfermedades relacionadas con RIPK1.
Bibliography:Application Number: MX20240005063