ANTI-CD3-BINDING DOMAINS AND ANTIBODIES COMPRISING THEM, AND METHODS FOR THEIR GENERATION AND USE

Anti-CD3 binding domains and antibodies comprising them, including multispecific antibodies, with, inter alia, desirable T-cell activation and (re)directed target cell killing potency and developability, profiles are provided, as well as methods for their identification, isolation, and generation, a...

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Bibliographic Details
Main Authors LEUNG Monica Wai Ling, VASQUEZ Maximiliano, KRAULAND Eric, WALKER Laura M, PEJCHAL Robert
Format Patent
LanguageEnglish
Spanish
Published 10.05.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Anti-CD3 binding domains and antibodies comprising them, including multispecific antibodies, with, inter alia, desirable T-cell activation and (re)directed target cell killing potency and developability, profiles are provided, as well as methods for their identification, isolation, and generation, and methods for their preparation and use. Reagents for identifying, isolating, selecting, generating and characterizing CD3 binding domains and antibodies comprising them are also provided. Se proporcionan dominios de unión anti-CD3 y anticuerpos que los comprenden, que incluyen anticuerpos multiespecíficos, con, entre otros, la activación conveniente de células T y la potencia (re)dirigida de destrucción de células diana y los perfiles de capacidad de desarrollo, así como también métodos para su identificación, aislamiento y generación, y métodos para su preparación y uso. También se proporcionan reactivos para identificar, aislar, seleccionar, generar y caracterizar dominios de unión a CD3 y anticuerpos que los comprenden.
Bibliography:Application Number: MX20240005009