PYRIDINYLACETAMIDE DERIVATIVES AS SODIUM CHANNEL ACTIVATORS

• Main Authors: BURFORD Kristen, MUNUGANTI Ravi, LOFSTRAND Verner, CLEMENT Helen, CHARIFSON Paul, ZHANG Wei, WESOLOWSKI Steve, SUN Shaoyi, SABBATANI Juliette, CLARK Michael, RAJAMANI Ramkumar, JOHNSTONE Shawn, KIM Jung Yun, SCHOLTES Jan Felix
• Format: Patent
• Language: English; Spanish
• Published: 04.06.2024
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure is directed to compounds of formula (I):, wherein R1, R2, R3, R3a, R4, Y, and X are as described herein, as stereoisomers, enantiomers, or tautomers thereof or mixtures thereof; or pharmaceutically acceptable salts, solvates, or prodrugs thereof, and pharmaceutical compositions comprising the compounds of formula (I), as described herein, which are useful as voltage-gated sodium channel modulators and are therefore are useful in treating seizure disorders such as epilepsy. La presente divulgación está dirigida a compuestos de fórmula (I): (ver formula), en donde R1 , R2 , R3 , R3a, R4 Y y X son como se describen en el presente documento, como estereoisómeros, enantiómeros o tautómeros de estos o mezclas de estos; o sales, solvatos o profármacos farmacéuticamente aceptables de estos, y composiciones farmacéuticas que comprenden los compuestos de fórmula (I), como se describe en el presente documento, que son útiles como moduladores de los canales de sodio dependientes de voltaje y, por lo tanto, son útiles en el tratamiento de trastornos convulsivos tales como la epilepsia.