COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES

• Main Authors: WOLFE Jia L, RECCHI Chiara, SAGOO Pervinder, GASPAR Bobby, MARKS-BLUTH Jonathon Simeon
• Format: Patent
• Language: English; Spanish
• Published: 23.05.2024
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPIRITS; VINEGAR; WINE

Described herein are compositions and methods for treating a subject having or at risk of developing an autoimmune disease. Using the compositions and methods of the disclosure, a patient may be provided pluripotent hematopoietic cells that are genetically modified to express an autoantigen-binding moiety (e.g., a chimeric antigen receptor) under the control of lineage-specific transcription regulatory elements that are active in CD4+CD25+ regulatory T (Treg) cells (e.g., a Foxp3 promoter). En el presente documento se describen composiciones y métodos para tratar a un sujeto que tiene o está en riesgo de desarrollar una enfermedad autoinmune. Usando las composiciones y métodos de la divulgación, a un paciente se le pueden proporcionar células hematopoyéticas pluripotentes que están genéticamente modificadas para expresar un resto de unión a autoantígeno (por ejemplo, un receptor de antígeno quimérico) bajo el control de elementos reguladores de la transcripción específicos del linaje que son activos en células T reguladoras (Treg) CD4+CD25+ (p. ej., un promotor Foxp3).