E3 LIGASE INHIBITORS AND METHODS OF USE THEREOF

The present disclosure provides pharmaceutical compositions and drug delivery devices comprising a compound of formula I, II, III, or IV. Methods are provided for inhibiting activity of an E3 ligase, involving contacting the E3 ligase with a compound of formula I, II, III, or IV. The present disclos...

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Bibliographic Details
Main Authors MANFORD Andrew Garret, WEHRI Edward Eric, RAPE Michael, SCHALETZKY Julia Sabine
Format Patent
LanguageEnglish
Spanish
Published 08.03.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure provides pharmaceutical compositions and drug delivery devices comprising a compound of formula I, II, III, or IV. Methods are provided for inhibiting activity of an E3 ligase, involving contacting the E3 ligase with a compound of formula I, II, III, or IV. The present disclosure provides various treatment methods involving administration of such compounds. La presente divulgación proporciona composiciones farmacéuticas y dispositivos de administración de fármacos que comprenden un compuesto de fórmula I, II, III o IV. Se proporcionan métodos para inhibir la actividad de una ligasa E3, que implican poner en contacto la ligasa E3 con un compuesto de fórmula I, II, III o IV. La presente descripción proporciona varios métodos de tratamiento que implican la administración de dichos compuestos.
Bibliography:Application Number: MX20230015239