PROCESS FOR THE PREPARATION OF NLRP3 INHIBITORS

• Main Authors: TOSATTI Paolo, PALGUNA Jetta, CINQUALBRE Josephine Eliette Françoise, MONDIÈRE Régis Jean Georges, FRASER Paul, BHARATHA Mallesh
• Format: Patent
• Language: English; Spanish
• Published: 29.04.2024
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present invention relates to intermediates and processes useful for preparing 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamo yl)piperidine-4-sulfonamide and salts thereof. The present invention further relates to 1-ethyl-N-((1,2,3,5,6,7- hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof when prepared by such processes and to associated pharmaceutical compositions and uses for the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition. La presente invención se refiere a intermediarios y procesos útiles para preparar 1-etil-N-((1,2,3,5,6,7-hexahidro-s-indacen-4- il)carbamoil)piperidin-4-sulfonamida y sales de la misma. La presente invención se refiere además a 1-etil-N-((1,2,3,5,6,7-hexa hidro-s-indacen-4-il)carbamoil)piperidin-4-sulfonamida y sales de la misma cuando se prepara mediante tales procesos y a composiciones farmacéuticas asociadas y usos para el tratamiento y prevención de trastornos médicos y enfermedades, más especialmente, mediante inhibición de NLRP3.