DETECTION OF A CHEMICAL SPECIES IN THE SWEAT OF A SUBJECT

• Main Authors: FAVRE Gilles, BEDIOUI Fethi, GRIVEAU Sophie, SELLA Catherine, AMATORE Christian, CHEN Yong, THOUIN Laurent
• Format: Patent
• Language: English; Spanish
• Published: 18.01.2024
• Subjects: DIAGNOSIS; HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATIONTECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING ORPROCESSING OF MEDICAL OR HEALTHCARE DATA; HUMAN NECESSITIES; HYGIENE; IDENTIFICATION; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; MEDICAL OR VETERINARY SCIENCE; PHYSICS; SURGERY

The invention relates to a detection apparatus for being placed on an area of investigation of an epidermis of a human or animal subject in order to detect at least nitric oxide dissolved in the sweat, said apparatus comprising: a structure (1) defining a microfluidic circuit for conducting a flow of sweat, the structure comprising an inlet port (4) allowing the sweat to pass from the epidermis, the microfluidic circuit comprising at least one microfluidic channel (9) in communication with the inlet port, at least one electrochemical sensor (10) comprising at least four electrodes arranged in series in a longitudinal direction of the microfluidic channel, the at least four electrodes comprising a reference electrode, at least two working electrodes and a counter electrode, the electrochemical sensor being configured to produce a signal representing a concentration of nitric oxide and further to perform depletion and/or to produce a signal representing a flow rate of the flow of sweat. Un aparato de detección para colocar en una zona de investigación de una epidermis de un sujeto humano o animal, para detectar al menos el óxido nítrico disuelto en el sudor, comprendiendo el aparato: una estructura (1) que define un circuito microfluídico para guiar un flujo de sudor, comprendiendo la estructura un orificio de entrada (4) que permite el paso del sudor desde la epidermis, el circuito microfluídico comprende al menos un canal microfluídico (9) en comunicación con el orificio de entrada, al menos un sensor electroquímico (10) que comprende al menos cuatro electrodos dispuestos sucesivamente en una dirección longitudinal del canal microfluídico, comprendiendo los al menos cuatro electrodos un electrodo de referencia, al menos dos electrodos de trabajo y un contraelectrodo, estando configurado el sensor electroquímico para producir una señal que es representativa de una concentración de óxido nítrico y además para implementar un agotamiento y/o para producir una señal que es representativa de un caudal del flujo de sudor.