COMBINATION THERAPIES WITH ANTI-CD38 ANTIBODIES AND PARP OR ADENOSINE RECEPTOR INHIBITORS

• Main Author: ARIAS Diana Alvarez
• Format: Patent
• Language: English; Spanish
• Published: 14.11.2023
• Subjects: AGRICULTURE; ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; CHEMISTRY; FISHING; FORESTRY; HUMAN NECESSITIES; HUNTING; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; NEW BREEDS OF ANIMALS; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; TRAPPING

This invention relates to methods and compositions for treating a disease by administering a combination therapy comprising an anti- CD38 antibody and a poly ADR ribose polymerase inhibitor (PARPi); an anti-CD38 antibody and an adenosine receptor antagonist; or an anti- CD38 antibody, a PARPi and an adenosine receptor antagonist, to a subject (e.g., a human patient) in need thereof. Esta invención se relaciona con métodos y composiciones para tratar una enfermedad al administrar una terapia de combinación que comprende un anticuerpo anti-CD38 y un inhibidor de poli ADP ribosa polimerasa (PARPi); un anticuerpo anti-CD38 y un antagonista del receptor de adenosina o un anticuerpo anti-CD38, un PARPi y un antagonista del receptor de adenosina, a un sujeto (p. ej., un paciente humano) que lo necesite.