MACROCYCLES CONTAINING A 1,3,4-OXADIAZOLE RING FOR USE AS MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulato...

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Main Authors BAEK Minson, STURINO Claudio, CLEVELAND Thomas, RAMTOHUL Yeeman K, GALLANT Michel, LATERREUR Julie, BECHARA William Schulz, HADIDA RUAH Sara Sabina, REDDY Thumkunta Jagadeeswar, GROOTENHUIS Peter Diederik Jan, PARASELLI Prasuna, BOOKSER Brett C, MILLER Mark Thomas, COON Timothy, ZHOU Jinglan, CLEMENS Jeremy J, VALDEZ Lino
Format Patent
LanguageEnglish
Spanish
Published 25.07.2023
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:This disclosure provides modulators of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR), pharmaceutical compositions containing at least one such modulator, methods of treatment of cystic fibrosis using such modulators and pharmaceutical compositions, and processes for making such modulators. La descripción proporciona moduladores del regulador de la conductancia transmembrana de la fibrosis quística (CFTR), composiciones farmacéuticas que contienen al menos uno de tales moduladores, métodos de tratamiento de la fibrosis quística que usan tales moduladores y composiciones farmacéuticas y procesos de fabricación de tales moduladores. (ver Fórmula).
Bibliography:Application Number: MX20230005721