METHODS FOR MAKING, COMPOSITIONS COMPRISING, AND METHODS OF USING REJUVENATED T CELLS

• Main Authors: TAMAOKI Naritaka, YAMAZAKI Yasuhiro, RESTIFO Nicholas, KLAUSNER Richard D, VIZCARDO SAKODA Raul E, MAEDA Takuya, HUANG Yin
• Format: Patent
• Language: English; Spanish
• Published: 09.08.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present disclosure relates generally to methods of producing rejuvenated T cells, comprising, contacting T cells with at least one reprogramming factor and reactivating the contacted cells; and compositions and methods of using same. The present disclosure also describes cell populations prepared according to methods described herein. The disclosure also provides for methods of treating patients using cell populations prepared by the methods described herein. La presente descripción se refiere en general a métodos de producción de células T rejuvenecidas, que comprenden poner en contacto células T con al menos un factor de reprogramación y reactivar las células contactadas y composiciones y métodos de uso de las mismas. La presente descripción también describe poblaciones de células preparadas de acuerdo con los métodos descritos en la presente. La descripción también proporciona métodos de tratamiento de pacientes usando poblaciones de células preparadas mediante los métodos descritos en la presente.