MESENCHYMAL STEM CELLS CO-EXPRESSING CXCR4 AND IL-10 AND USES THEREOF

• Main Authors: YÁÑEZ GONZÁLEZ Rosa María, GARCÍA-OLMO Damián, BUEREN RONCERO Juan Antonio, GARIN FERREIRA Marina Inmaculada, HERNANDO RODRÍGUEZ Miriam, FERNÁNDEZ GARCÍA María, HERVÁS-SALCEDO Rosario, LÓPEZ SANTALLA Mercedes, GARCÍA-ARRANZ Mariano
• Format: Patent
• Language: English; Spanish
• Published: 26.05.2023
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

The present invention refers to mesenchymal stem cells (MSCs) characterized in that they are transduced with an integrative expression vector in order to stably co-express the chemokine receptor type 4 CXCR4 and the interleukin IL-10. The present invention also refers to the use of said MSCs as a medicament, particularly in the treatment of inflammatory and/or autoimmune diseases. La presente invención se refiere a células madre mesenquimales (MSC) caracterizadas porque son transducidas por un vector de expresión integrativa para coexpresar de manera estable el receptor de quimiocina tipo 4 CXCR4 y la interleucina IL-10. La presente invención también se refiere al uso de las MSC como un medicamento, particularmente en el tratamiento de enfermedades inflamatorias y/o autoinmunes.