METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS

• Main Authors: ENGELS Boris, HACK Anniesha, SHARMA Sujata, GREENE Michael, R, PRICE Andrew, LIM Hyungwook, DRANOFF Glenn, KODRASI Olja, BONDANZA Attilio, PRATICO Elizabeth, Dorothy, STEIN Andrew, Marc, ZHU Xu, CARBONNEAU Seth, BROGDON Jennifer, SOHONI Akash, TREANOR Louise, GUIMARAES Carla, Patricia, Pinto, HILD Marc, Horst, Peter
• Format: Patent
• Language: English; Spanish
• Published: 23.09.2022
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; COMPOSITIONS THEREOF; CULTURE MEDIA; ENZYMOLOGY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MICROORGANISMS OR ENZYMES; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS; SPIRITS; VINEGAR; WINE

This disclosure provides methods of making immune effector cells (for example, T cells, NK cells) that comprise (i) a nucleic acid molecule that encodes a controllable chimeric antigen receptor (CCAR) or (ii) a nucleic acid molecule that encodes a CAR and a regulatory molecule, and compositions generated by such methods. La presente divulgación proporciona métodos para producir células efectoras inmunitarias (por ejemplo, células T, células NK) que comprenden (i) una molécula de ácido nucleico que codifica un receptor de antígeno quimérico controlable (CCAR) o (ii) una molécula de ácido nucleico que codifica un CAR y una molécula reguladora, y composiciones generadas por dichos métodos.