CD19-DIRECTED CHIMERIC ANTIGEN RECEPTOR T CELL COMPOSITIONS AND METHODS AND USES THEREOF

• Main Authors: POLTORAK Mateusz Pawel, CASPARY Robert Guy, WU Kaida, BRIGGS Adrian Wrangham, KILAVUZ Nurgul, KUGLER David G, WESTOBY Matthew, HEGE Kristen, GERMEROTH Lothar, BASHOUR Keenan, CHAN Calvin, SALMON Ruth Amanda, BATUREVYCH Oleksandr, BURGESS Michael, STEMBERGER Christian, VARUN Divya
• Format: Patent
• Language: English; Spanish
• Published: 14.02.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided in some aspects are compositions of cells for treating subjects with disease and conditions such as non-Hodgkin's lymphoma (NHL), and related methods, compositions, uses and articles of manufacture. In some embodiments, the disease or condition is a B-cell non-Hodgkin lymphoma (B-cell NHL). The cells generally express recombinant receptors such as chimeric antigen receptors (CARs) for targeting an antigen, such as CD 19, on cells of the lymphoma. En algunos aspectos se proporcionan composiciones de células para tratar sujetos con enfermedad y condiciones tal como linfoma no de Hodgkin (NHL), y métodos, composiciones, usos y artículos de fabricación relacionados. En algunas modalidades, la enfermedad o condición es un linfoma no de Hodgkin de células B (NHL de células B). Las células en general expresan receptores recombinantes tal como receptores de antígeno quimérico (CAR) para dirigirse a un antígeno, tal como CD19, en células del linfoma.