1,2,4-OXADIAZOLE DERIVATIVES AS LIVER X RECEPTOR AGONISTS

Provided herein are compounds and pharmaceutical compositions useful for treating meibomian gland dysfunction (MGD), comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I) or a compound of Formula (I'), or pharmaceutical composition...

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Main Authors HUANG Zhihong, SHAW Duncan, LINKENS Kathryn Taylor, SMITH Jeffrey, HARDY Declan, MA Fupeng, FLYER Alec Nathanson, BOSS Kelly D, MOLTENI Valentina, SOLOVAY Catherine Fooks, LOREN Jon Christopher, FAN Yi
Format Patent
LanguageEnglish
Spanish
Published 02.08.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds and pharmaceutical compositions useful for treating meibomian gland dysfunction (MGD), comprising administering to a subject in need thereof a therapeutically effective amount of a compound of Formula (I) or a compound of Formula (I'), or pharmaceutical composition described herein. Se proporcionan aquí compuestos y composiciones farmacéuticas útiles para el tratamiento de la disfunción de la glándula de Meibomio (MGD), que comprende administrar a un sujeto que lo necesita una cantidad terapéuticamente eficaz de un compuesto de Fórmula (I) o un compuesto de Fórmula (I'), o una composición farmacéutica descripta en la presente memoria. (ver Fórmulas).
Bibliography:Application Number: MX2022006151