POROUS GLUCOMANNAN SCAFFOLDS AND METHODS FOR PRODUCING THE SCAFFOLDS

• Main Authors: JUDD Justin, LEE C. Chang I, PARK Chan Ju
• Format: Patent
• Language: English; Spanish
• Published: 16.05.2022
• Subjects: BANDAGES, DRESSINGS OR ABSORBENT PADS; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; FILTERS IMPLANTABLE INTO BLOOD VESSELS; FIRST-AID KITS; FOMENTATION; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; PROSTHESES; TREATMENT OR PROTECTION OF EYES OR EARS

The present invention provides methods of producing a glucomannan scaffold having uniform porosity and interconnectivity. The scaffold is prepared by maintaining a glucomannan gel under conditions prescribed to meet a length of time in the solidification phase. The method improves product consistency, while reducing manufacturing waste. The resulting glucomannan scaffold is capable of promoting cell growth and suitable for three- dimensional tissue culture and engineering. La presente invención proporciona métodos para producir un andamio de glucomanano que tienen porosidad uniforme e interconectividad. El andamio se prepara manteniendo un gel de glucomanano bajo condiciones prescritas para cumplir una duración en fase de solidificación. El método mejora la consistencia del producto, mientras reduce los desechos de preparación. El andamio de glucomanano resultante es capaz de promover el crecimiento celular y es adecuado para cultivo e ingeniería de tejidos tridimensional.