AMIDE-LINKED, AMINOBENZAZEPINE IMMUNOCONJUGATES, AND USES THEREOF

The invention provides immunoconjugates of Formula I comprising an antibody linked by conjugation to one or more 8-amido-2-aminobenzazepine derivatives. The invention also provides 8-amido-2-aminobenzazepine derivative intermediate compositions comprising a reactive functional group. Such intermedia...

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Bibliographic Details
Main Authors SAFINA Brian, KUDIRKA Romas, ZHOU Matthew
Format Patent
LanguageEnglish
Spanish
Published 02.05.2022
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The invention provides immunoconjugates of Formula I comprising an antibody linked by conjugation to one or more 8-amido-2-aminobenzazepine derivatives. The invention also provides 8-amido-2-aminobenzazepine derivative intermediate compositions comprising a reactive functional group. Such intermediate compositions are suitable substrates for formation of the immunoconjugates through a linker or linking moiety. The invention further provides methods of treating cancer with the immunoconjugates. La invención proporciona inmunoconjugados de Fórmula I que comprenden un anticuerpo unido por conjugación a uno o más derivados de 8-amido-2-aminobenzazepina. La invención también proporciona composiciones intermedias de derivados de 8-amido-2-aminobenzazepina que comprenden un grupo funcional reactivo. Tales composiciones intermedias son sustratos adecuados para la formación de los inmunoconjugados a través de un enlazador o resto enlazador. La invención proporciona además métodos para tratar el cáncer con los inmunoconjugados.
Bibliography:Application Number: MX2022003740