TREATMENT OF CANCER WITH A COMBINATION OF AN ANTIBODY THAT BINDS LGR5 AND EGFR AND A TOPOISOMERASE I INHIBITOR

The invention describes antibodies or functional parts, derivatives and/or analogues thereof that comprise a variable domain that binds an extracellular part of EGFR and a variable domain that binds an extracellular part of LGR5 for use in the treatment of cancer wherein the antibody or functional p...

Full description

Saved in:
Bibliographic Details
Main Authors THROSBY Mark, WASSERMAN Ernesto Isaac
Format Patent
LanguageEnglish
Spanish
Published 17.03.2022
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
Online AccessGet full text

Cover

More Information
Summary:The invention describes antibodies or functional parts, derivatives and/or analogues thereof that comprise a variable domain that binds an extracellular part of EGFR and a variable domain that binds an extracellular part of LGR5 for use in the treatment of cancer wherein the antibody or functional part, derivative and/or analogue thereof is administered with a topoisomerase I inhibitor. La invención describe anticuerpos o partes, derivados y/o análogos funcionales de los mismos que comprenden un dominio variable que se une a una parte extracelular de EGFR y un dominio variable que se une a una parte extracelular de LGR5 para usar en el tratamiento del cáncer en donde el anticuerpo o parte, derivado y/o análogo funcional del mismo se administra con un inhibidor de topoisomerasa I.
Bibliography:Application Number: MX2022002096