DOPAMINE-Β-HYDROXYLASE INHIBITORS

• Main Authors: CARDONA Francisco, KISS Laszlo, BELIAEV Alexander, SOARES DA SILVA Patricio, PINTO Rui, PALMA Nuno, ROSSI Tino
• Format: Patent
• Language: English; Spanish
• Published: 24.01.2022
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

This invention relates to: (a) compounds of formula I (with R1 to R5 and A as defined herein) and pharmaceutically acceptable salts or solvates thereof that are useful as dopamine-β-hydroxylase inhibitors; (b) pharmaceutical compositions comprising such compounds, salts or solvates; (c) the use of such compounds, salts or solvates in therapy; (d) therapeutic methods of treatment using such compounds, salts or solvates; and (e) processes and intermediates useful for the synthesis of such compounds. La presente se refiere a: (a) compuestos de la fórmula I (con R1 a R5 y A de acuerdo con lo definido en la presente memoria) y sales o solvatos aceptables para uso farmacéutico de los mismos que son útiles como inhibidores de dopamina-ß-hidroxilasa; (b) composiciones farmacéuticas que comprenden tales compuestos, sales o solvatos; (c) el uso de tales compuestos, sales o solvatos en una terapia; (d) métodos terapéuticos de tratamiento por el uso de tales compuestos, sales o solvatos; y (e) procesos e intermedios útiles para la síntesis de tales compuestos. (ver Fórmula).