PHARMACEUTICAL COMPOSITIONS COMPRISING (S)-4-(4-(4-(((2-(2,6-DIOX OPIPERIDIN-3-YL)-1-OXOISOINDOLIN-4-YL)OXY)METHYL) BENZYL)PIPERAZIN-1-YL)-3-FLUOROBENZONITRILE AND METHODS OF USING THE SAME

• Main Authors: AGRAWAL Anjali, CHEN Ming J, VISKY Dora, THOOL Prajwal Gunwanth, KARKI Shyam Babu, RUIMIN Xie
• Format: Patent
• Language: English; Spanish
• Published: 13.10.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided herein are pharmaceutical compositions (e.g., oral dosage formulations) comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-l-oxoisoindolin-4- yl)oxy)methyl)benzyl)piperazin-l-yl)-3-fluorobenzonitrile, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, and a carrier or diluent. Also provided herein are methods of preparing and methods of using the pharmaceutical compositions. En el presente documento se proporcionan composiciones farmacéuticas (p. ej., formulaciones de dosificación oral) que comprenden (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-il)-1-oxoisoindo lin-4- il) oxi) metil) bencil) piperazin-1-il)-3-fluorobenzonitril o, o un enantiómero, una mezcla de enantiómeros, un tautómero, un isotopólogo o una sal farmacéuticamente aceptable de este, y un portador o diluyente. También se proporcionan en el presente documento métodos de preparación y métodos de uso las composiciones farmacéuticas.