INDUSTRIAL PREPARATION METHOD OF LUTEIN AND MARIGOLD FLAVONE

• Main Authors: GAO Wei, WU Di, AN Xiaodong, WANG Huanhuan, LIAN Yunhe
• Format: Patent
• Language: English; Spanish
• Published: 02.11.2022
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; COMPOUNDS OF UNKNOWN CONSTITUTION; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

The present invention relates to an industrial preparation method of lutein and marigold flavone. Main improvement points thereof are: mixing a petroleum ether and a flavone extraction solvent; extracting marigold particles; adding a strong-polarity solvent to the flavone extraction solvent after extraction is finished; and further promoting separation of the lutein and the marigold flavone. The present invention uses a double-solvent extraction method, so that the extraction efficiency is improve; the purity of the marigold flavone is improved; furthermore, the method in the present invention is simple in steps and low in costs, and is applicable to industrial large-scale production; the purity of the extracted marigold flavone is high; and the marigold flavone has various bioactivities and has a wide application prospect. La presente invención se refiere a un método de preparación industrial de luteína y flavona de caléndula, que comprende: a) mezclar éter de petróleo y un solvente de extracción de flavona y realizar la extracción en partículas de caléndula para obtener una solución del extracto mezclado; 2) añadir un solvente de polaridad fuerte con una polaridad mayor que la del solvente de extracción flavona a la solución del extracto mezclado, agitar bien y dejar reposar para estratificar para obtener una fase de luteína y una fase de flavona, separar la fase de luteína y la fase de flavona, y retirar el éter de petróleo o el solvente de extracción fe flavona, respectivamente, para obtener flavona de caléndula y un extracto de luteína.