METHODS AND COMPOSITIONS FOR INCREASING PROTEIN EXPRESSION AND/OR TREATING A HAPLOINSUFFICIENCY DISORDER

A tRNA that hybridizes to a non-optimal codon can be used to increase expression in a mammalian cell of a gene product encoded by a gene containing the non-optimal codon or to treat a haploinsufficiency disorder in a subject having a haploinsufficient gene containing the non-optimal codon. Se puede...

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Bibliographic Details
Main Authors SWEET Thomas, M COLLER Jeffery, LODISH Harvey
Format Patent
LanguageEnglish
Spanish
Published 24.08.2021
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Summary:A tRNA that hybridizes to a non-optimal codon can be used to increase expression in a mammalian cell of a gene product encoded by a gene containing the non-optimal codon or to treat a haploinsufficiency disorder in a subject having a haploinsufficient gene containing the non-optimal codon. Se puede usar un ARNt que hibrida con un codón no óptimo para aumentar la expresión en una célula de mamífero de un producto génico codificado por un gen que contiene el codón no óptimo o para tratar un trastorno por haploinsuficiencia en un sujeto que tiene un gen haploinsuficiente que contiene el codón no óptimo.
Bibliography:Application Number: MX20210003567