METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS

• Main Author: ROTHBAUM Wayne
• Format: Patent
• Language: English; Spanish
• Published: 11.08.2021
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

Therapeutic methods and pharmaceutical compositions for treating a myeloproliferative neoplasm (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis, are described. In certain embodiments, the invention includes therapeutic methods of treating a MPN using a combination of a compound of Formula (I) or Formula (II) with a therapeutic agent selected from the group consisting of a JAK inhibitor, an IDH inhibitor, a PD-1 inhibitor, a PD-L1 inhibitor, a PD-L2 inhibitor, an interferon, a PI3K inhibitor, an AKT inhibitor, an mTOR inhibitor, a nucleoside analog, and combinations thereof. Se describen métodos terapéuticos y composiciones farmacéuticas para tratar una neoplasia mieloproliferativa (MPN), que incluye policitemia vera (PV), trombocitemia esencial (ET) y mielofibrosis. En ciertas modalidades, la invención incluye métodos terapéuticos para tratar una MPN mediante el uso de una combinación de un compuesto de Fórmula (I) o Fórmula (II) con un agente terapéutico seleccionado del grupo que consiste en un inhibidor de JAK, un inhibidor de IDH, un inhibidor de PD-1, un inhibidor de PD-L1, un inhibidor de PD-L2, un interferón, un inhibidor de PI3K, un inhibidor de AKT, un inhibidor de mTOR, un análogo de nucleósido y sus combinaciones.