METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS
Therapeutic methods and pharmaceutical compositions for treating a myeloproliferative neoplasm (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis, are described. In certain embodiments, the invention includes therapeutic methods of treating a MPN using a combi...
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Main Author | |
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Format | Patent |
Language | English Spanish |
Published |
11.08.2021
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Subjects | |
Online Access | Get full text |
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Summary: | Therapeutic methods and pharmaceutical compositions for treating a myeloproliferative neoplasm (MPN), including polycythemia vera (PV), essential thrombocythemia (ET), and myelofibrosis, are described. In certain embodiments, the invention includes therapeutic methods of treating a MPN using a combination of a compound of Formula (I) or Formula (II) with a therapeutic agent selected from the group consisting of a JAK inhibitor, an IDH inhibitor, a PD-1 inhibitor, a PD-L1 inhibitor, a PD-L2 inhibitor, an interferon, a PI3K inhibitor, an AKT inhibitor, an mTOR inhibitor, a nucleoside analog, and combinations thereof.
Se describen métodos terapéuticos y composiciones farmacéuticas para tratar una neoplasia mieloproliferativa (MPN), que incluye policitemia vera (PV), trombocitemia esencial (ET) y mielofibrosis. En ciertas modalidades, la invención incluye métodos terapéuticos para tratar una MPN mediante el uso de una combinación de un compuesto de Fórmula (I) o Fórmula (II) con un agente terapéutico seleccionado del grupo que consiste en un inhibidor de JAK, un inhibidor de IDH, un inhibidor de PD-1, un inhibidor de PD-L1, un inhibidor de PD-L2, un interferón, un inhibidor de PI3K, un inhibidor de AKT, un inhibidor de mTOR, un análogo de nucleósido y sus combinaciones. |
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Bibliography: | Application Number: MX20200012503 |