COMPOSITIONS AND METHODS FOR TREATING SEVERE CONSTIPATION

• Main Authors: HUBBARD Brian K, SERRANO-WU Michael H
• Format: Patent
• Language: English; Spanish
• Published: 25.01.2023
• Subjects: HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The present disclosure provides methods related to treating or preventing gastrointestinal dysfunction in a subject in need thereof, which include the use of a diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor. The disclosure also provides pharmaceutical compositions comprising a DGAT1 inhibitor, or pharmaceutically acceptable salts or esters thereof, useful for the treatments described herein. La presente descripción proporciona métodos relacionados con el tratamiento o la prevención de la disfunción gastrointestinal en un sujeto que lo necesita, que incluyen el uso de un inhibidor de la diacilglicerol O-aciltransferasa 1 (DGAT1). La descripción también proporciona composiciones farmacéuticas que comprenden un inhibidor de DGAT1, o sales o ésteres farmacéuticamente aceptables de este, útiles para los tratamientos descritos en la presente.