COMPOSITIONS AND METHODS FOR TREATMENT OF INSULIN RESISTANCE

• Main Authors: MORTON George C, CHILDERS Wayne E, MERALI Salim, BARRERO Carlos A
• Format: Patent
• Language: English; Spanish
• Published: 08.01.2021
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PHYSICS; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; TESTING

In certain embodiments, this disclosure relates to methods of treating or preventing type 2 diabetes, pre-diabetes and conditions characterized by an increase in the levels of AIC, glucose, insulin, homeostasis model of assessment of insulin resistance (HOMA-IR), oxidative stress in adipose tissue, and earbonvlation of GLUT4 comprising administering an effective amount of a compound of Formula I-III as described herein, to a subject in need thereof. En ciertas modalidades, esta descripción se refiere a métodos para tratar o evitar la diabetes tipo 2, la prediabetes y las afecciones caracterizadas por un aumento en los niveles de A1C, glucosa, insulina, modelo homeostático para evaluar la resistencia a la insulina (HOMA-IR), estrés oxidativo en el tejido adiposo y carbonilación de GLUT4, que comprende administrar una cantidad efectiva de un compuesto de las Fórmulas I-III como se describe en la presente descripción, a un sujeto que lo necesite..