METHODS AND COMPOSITIONS FOR TREATING CANCER WITH ECM-AFFINITY PEPTIDES LINKED TO IMMUNOTHERAPEUTIC ANTIBODIES

• Main Authors: ISHIHARA Jun, HUBBELL Jeffrey A, SWARTZ Melody, ISHIHARA Ako, FUKUNAGA Kazuto
• Format: Patent
• Language: English; Spanish
• Published: 28.07.2020
• Subjects: CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

The methods and compositions described herein address the need in the art by providing compositions and methods for a therapy with an antibody that is specifically targeted to and/or retained intra- or peri-tumorally, limiting systemic exposure and reducing side-effects. Accordingly, aspects of the disclosure relate to a composition comprising an immunotherapeutic antibody operatively linked to an extracellular matrix (ECM)-affinity peptide. An ECM-affinity peptide is one that has affinity for an extracellular matrix protein. Los métodos y composiciones descritos en la presente abordan la necesidad en la técnica al proporcionar composiciones y métodos para una terapia con un anticuerpo que está específicamente dirigido y/o retenido intratumoralmente o peritumoralmente, limitando la exposición sistémica y reduciendo los efectos secundarios. Por consiguiente, los aspectos de la descripción se refieren a una composición que comprende un anticuerpo inmunoterapéutico ligado operativamente a un péptido de afinidad de matriz extracelular (MEC). Un péptido de afinidad de MEC es uno que tiene afinidad por una proteína de matriz extracelular.