METHODS OF TREATING INFLAMMATORY DISORDERS WITH MULTIVALENT FC COMPOUNDS
The present invention provides methods for the identification of patients with an inflammatory or autoimmune disease that demonstrate an inadequate response to treatment with a multi-Fc therapeutic, and the determination of an optimal dose of a multi-Fc therapeutic for said patient based on the pati...
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Main Authors | , |
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Format | Patent |
Language | English Spanish |
Published |
14.08.2019
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Subjects | |
Online Access | Get full text |
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Summary: | The present invention provides methods for the identification of patients with an inflammatory or autoimmune disease that demonstrate an inadequate response to treatment with a multi-Fc therapeutic, and the determination of an optimal dose of a multi-Fc therapeutic for said patient based on the patient's circulating levels of inactivated C3b (iC3b) and/or additional complement components that may be employed as a surrogate for iC3b based on an analogous response to multi-Fc therapeutics. The present invention further provides for improvements in the use of such multi-Fc therapeutics in the treatment of autoimmune and inflammatory diseases.
La presente invención provee métodos para la identificación de pacientes con una enfermedad autoinmunitaria o inflamatoria que demuestran una respuesta inadecuada al tratamiento con un agente terapéutico multi-Fc y la determinación de una dosis óptima de un agente terapéutico multi-Fc para dicho paciente con base en los niveles en circulación del paciente de C3b inactivado (iC3b) y/o componentes del complemento adicionales que se pueden emplear como un sustituto para iC3b con base en una respuesta análoga a los agentes terapéuticos multi-Fc. La presente invención provee además mejoras en el uso de tales agentes terapéuticos multi-Fc en el tratamiento de enfermedades autoinmunitarias e inflamatorias. |
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Bibliography: | Application Number: MX20190006141 |