BICYCLIC NITROGENATED HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

• Main Authors: Naotake KOBAYASHI, Hiroyuki KAI, Eiichi KOJIMA, Tomoyuki OGAWA, Toru YAMADA, Koji MASUDA, Shuichi SUGIYAMA
• Format: Patent
• Language: English; Spanish
• Published: 05.08.2019
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS

Provided are: a novel compound having a P2X7 receptor inhibitory activity; and a pharmaceutical composition having a P2X7 receptor inhibitory activity. A compound represented by formula (I) (wherein Z1 represents C(R4) or the like; R4 represents a hydrogen atom or the like; Z2 represents C(R5a)(R5a') or the like; a broken line represents the presence or absence of a bond, wherein, when the broken line represents the presence of a bond, R5a' is absent; R5a and R5a' independently represent a hydrogen atom or the like; the ring Q represents a substituted or unsubstituted 5-membered non-aromatic heterocyclic ring or the like; Y1 represents O or the like; R2a represents a group represented by the formula -(C(R2a')(R2b'))n-R1 ; R2b represents a hydrogen atom or the like; R2a' and R2b' independently represent a hydrogen atom or the like; R1 represents a substituted or unsubstituted aromatic carbocyclic group or the like; X represents N(R7a) or the like; R7a represents a hydrogen atom or the like; R3 represents a substituted or unsubstituted aromatic carbocyclic group or the like; n represents an integer of 0 to 4; and m represents an integer of 0 to 4), or a pharmaceutically acceptable salt thereof. Se proporcionan un nuevo compuesto que tiene una actividad antagonista para el receptor P2X7, y una composición farmacéutica que tiene una actividad antagonista para el receptor P2X7. Un compuesto representado por la Fórmula (I): (ver Fórmula) en donde Z1 es C(R4) o similares; R4 es un átomo de hidrógeno o similares; Z2 es C(R5a) (R5a´) o similares; la línea discontinua representa la presencia o ausencia de un enlace; cuando la línea discontinua representa la presencia de un enlace, entonces R5a' está ausente; R5a R5a' son cada uno independientemente un átomo de hidrógeno o similares; el anillo Q es un heterociclo no aromático de 5 miembros sustituido o no sustituido o similares; Y1 es O o similares; R2a es un grupo representado por la fórmula: -(C(R2a') (R2b'))n- R1; R2b es un átomo de hidrógeno o similares; R2a' y R2b' son cada uno independientemente un átomo de hidrógeno o similares; R1 es carbociclilo aromático sustituido o no sustituido o similares; X es N(R7a) o similares; R7a es un átomo de hidrógeno o similares; R3 es carbociclilo aromático sustituido o no sustituido o similares; n es un número entero de 0 a 4 y m es un número entero de 0 a 4, o una sal farmacéuticamente aceptable del mismo.